GREEN COFFEE, KETONE AND GARCINIA ULTRA BLEND BIOCEUTICAL SUPPLEMENT
Green Coffee Bean, Raspberry Ketone & Garcinia Cambogia
We have combined 3 of the most popular and effective weight loss supplements on the market to make one extraordinary effective weight loss supplement for your convenience.
Capsules Per Container: 60
Bottle Color: White
Lid Color: Black
Green Coffee Bean
Although still relatively unknown to the general public, there is nonetheless considerable evidence to support the health benefits green coffee bean extract, including 2 very recent clinical trial results released in 2019. The primary constituent studied has been chlorogenic acid (CGA), a polyphenol with remarkable antioxidant properties . To date, green coffee bean extract has been clinically demonstrated to benefit adults in the following ways:
- Reduce abdominal fat –
- Reduce appetite , 
- Normalize blood glucose 
- Improve vascular function and blood pressure , 
- Improve sleep quality 
- Support cognitive ability 
Selected clinical findings
- Green Coffee Bean Abundant in Chlorogenic Acids Reduces Abdominal Fat in Overweight Adults: A Randomized, Double-Blind, Controlled Trial 
The components of green coffee beans that promote abdominal fat reduction are not clear. We investigated the effects of daily consumption of coffee enriched in chlorogenic acids (CGA) on abdominal fat area in a randomized, double-blind, parallel controlled trial. Healthy, overweight men and women (n = 150, body mass index (BMI) ≥25 to <30 kg/m2) were randomly allocated to high-CGA (369 mg CGA/serving) or control (35 mg CGA/serving) coffee groups. Instant coffee was consumed once daily for 12 weeks, with four-week pre- and post-observation periods. Abdominal fat area and anthropometric measurements were analyzed at baseline and at four, eight, and 12 weeks, and 142 subjects completed the trial. Visceral fat area (VFA), total abdominal fat area (TFA), body weight, and waist circumference significantly decreased in the CGA group compared with the control group, with a group × time interaction (p < 0.001, p = 0.001, p = 0.025, and p = 0.001, respectively). Changes in VFA and TFA from baseline to 12 weeks were significantly greater in the CGA group than in the control group (−9.0 ± 13.9 cm2 vs. −1.0 ± 14.3 cm2, p < 0.001; −13.8 ± 22.9 cm2 vs. −2.0 ± 16.2 cm2, p < 0.001). No severe adverse events occurred. Consumption of high-CGA coffee for 12 weeks by overweight adults might lower VFA, TFA, BMI, and waist circumference.
CGA= Chlorogenic Acids (main component of Green Coffee Extract)
Fig. 1. Control (n = 70 adults), CGA (n = 72 adults). VFA: visceral fat area, SFA: subcutaneous fat area, TFA: total fat area
* p < 0.05, ** p < 0.01, and *** p < 0.001, compared with the control group.
Previous clinical interventional studies of the components of green coffee beans were controversial and had limitations, such as being un-blinded, not placebo-controlled or having a small sample size and short duration. Until this study, no large-scale randomized clinical trials had been conducted comparing high levels of CGA from green coffee bean extract vs low levels of CGA, measuring abdominal fat accumulation. These researchers hypothesized that CGA-containing green coffee bean reduces abdominal fat area compared with common coffee beverages. This study compared the effects of the consumption of instant coffee with high CGA levels with that of conventional instant coffee with low CGA levels over the course of 12 weeks on the change in abdominal VFA, as the primary endpoint in overweight individuals, and safety in healthy overweight adult men and women.
In this study, the researchers assessed the effectiveness of daily consumption of high levels of green coffee bean extract CGA over the course of 12 weeks in healthy overweight adult men and women for reducing abdominal fat area, with visceral fat area (VFA) as the primary endpoint measure. A significant decrease in VFA was detected in cross-sectional CT images. The secondary outcomes were total fat area (TFA), body weight, body-mass index (BMI). Furthermore, according to the results of the diaries of subjects and physician interviews during the trial, there were no adverse events from consuming high levels of green coffee bean CGA. In a review article describing the effects of coffee on the risk of diabetes, previous researchers have determined that that caffeine and CGA have a synergistic body weight-reducing effect , which is why Umbrella Labs incorporates both caffeine and green coffee bean extract together. Previous studies reported benefits related to an increased CGA content, such as reductions in glucose absorption, body weight, body fat, and DNA damage , . Few randomized control trial studies, however, have described the influence of CGA on body fat or abdominal visceral fat accumulation.
In this trial, compared with the control group, the CGA group showed significant decreases in visceral fat at 12 weeks relative to baseline. Similar results were observed for total fat. Moreover, group × time interactions were observed for BMI, body weight, and WC, which showed significant decreases relative to the control group. These findings show that not only visceral fat, but also BMI and body weight were significantly decreased, revealing that CGA coffee has a body fat-reducing effect. Food intake and physical activity during the trial did not differ significantly between groups. The CGA coffee and control coffee were both instant black coffee with essentially the same amounts of caffeine and calories. Because the only difference between the components of each drink was the amount of CGA, these results suggest that CGA was responsible for the decreases in visceral fat, BMI, and body weight. Although no studies clearly demonstrate a relationship between oxidative stress and abdominal visceral fat, one study reported that oxidant components enhance the energy expenditure and fat oxidation effects of CGA-containing coffee . The mechanism underlying the effect of instant coffee containing high amounts of CGA and decreased amounts of oxidant components on decreasing abdominal visceral fat might involve both increased energy expenditure and increased fat burning.
According to a human clinical trial comparing daily consumption of roasted coffee containing CGA versus placebo coffee for one week, repeated consumption of CGA decreased the respiratory quotient and increased oxygen consumption , which means that both energy expenditure and fat burning were elevated. Furthermore, feeding green coffee bean extract containing CGA to mice with diet-induced obesity decreased body fat accumulation, with a dose-dependent decrease in body weight and accumulation of both visceral fat and liver fat . Although CGA reportedly has a hypotensive effect (ie. lowers blood pressure), no significant changes in blood pressure were observed in the present trial. Because this trial did not target a population with blood pressure classified as greater or equal to stage I hypertension, as in previous trials studying the hypotensive effect of CGA, they did not to observe any blood pressure-lowering effects. In terms of safety, although they found slight changes in the blood concentrations of potassium, the fluctuations were minor and unlikely to be clinically problematic. Moreover, urinalysis revealed no problematic changes, and no adverse events considered to be due to the test drink were reported. This study did have some limitations however. Firstly, the subjects were Japanese; thus, whether the same effects might occur in other populations (e.g., North American populations) remains unclear. Secondly, although CGA was the effective component in the coffee used in this trial, blood CGA concentrations were not measured. Thus, the direct relationships between the blood CGA concentration and the outcome measures (e.g., visceral fat) are unclear. Extending the test period might have revealed a clearer difference in the effect.
Ultimately, this clinical trial further strengthened the rationale for using green coffee bean extract CGA for abdominal fat reduction.
Raspberry Ketone (RK)
Only in the last few years have the true potential of raspberry ketones been realized, which include protection from oxidative stress, metabolism boosting, reduced inflammation, and weight loss. Raspberry ketones have now attracted mainstream media attention recently due to their promotion of weight loss. This attention seems to be rooted in research that reported a reduced weight gain after 5 and 10 weeks of raspberry ketone supplementation (2% of diet) along with a high-fat diet . The reason for the research as indicated by the authors was derived from recognizing structural similarities with capsaicin and synephrine (from various peppers), compounds known to exert anti-obese actions and alter fat metabolism. The study reported raspberry ketone supplementation prevented high-fat, diet-induced elevations in body weight and the weights of liver and visceral fat tissue. In addition, liver fat content was reduced, whereas hormone-driven fat burning was significantly increased in fat cells. Thus, raspberry ketones prevent and improve obesity and fatty liver by altering fat metabolism in very specific ways.
Selected pre-clinical findings
- Anti-obese action of raspberry ketone 
Raspberry ketone (RK) is a major aromatic compound of red raspberry (Rubus idaeus). The structure of RK is similar to the structures of capsaicin and synephrine, compounds known to exert anti-obese actions and alter the lipid metabolism. The present study was performed to clarify whether RK helps prevent obesity and activate lipid metabolism in rodents. To test the effect on obesity, our group designed the following in vivo experiments: 1) mice were fed a high-fat diet including 0.5, 1, or 2% of RK for 10 weeks; 2) mice were given a high-fat diet for 6 weeks and subsequently fed the same high-fat diet containing 1% RK for the next 5 weeks. RK prevented the high-fat-diet-induced elevations in body weight and the weights of the liver and visceral adipose tissues (epididymal, retroperitoneal, and mesenteric). RK also decreased these weights and hepatic triacylglycerol content after they had been increased by a high-fat diet. RK significantly increased norepinephrine-induced fat breakdown associated with the translocation of hormone-sensitive lipase from the cytosol to lipid droplets in rat epididymal fat cells. In conclusion, RK prevents and improves obesity and fatty liver. These effects appear to stem from the action of RK in altering the lipid metabolism, or more specifically, in increasing norepinephrine-induced fat breakdown in white fat cells.
Fig. 2. Effect of raspberry ketone on body weight (A) and the weights of the liver and various adipose (fat) tissues (B) in mice fed a high-fat diet for 10 weeks. The meaning of each symbol is indicated in the figure. Each value represents the mean of 6 mice; *p < 0.05 and **p < 0.01 vs. values in high-fat diet group. ND, normal diet; HFD, high-fat diet; RK, raspberry ketone.
Dietary sugars such as glucose and fructose are also known to increase fat accumulation. Raspberry ketone (RK) suppressed weight elevation in visceral and subcutaneous fate tissues induced by the over-intake of fructose. Given that RK reduces both fat- and sugar-induced fat accumulation, these authors hypothesized that its anti-obese action is conferred mainly during the stages of fat breakdown.
Based on previous work, this study examined the effect of RK on fat breakdown of white fat cells (ie. fat cells). The hormones norepinephrine and epinephrine are known to stimulate fat breakdown via beta-adrenergic receptor. Similarly, synephrine can activate in vitro fat breakdown in rat fat cells via activation of the same receptor (Carpene et al., 1999). This prompted us to examine the effect of RK on fat breakdown in rat epididymal fat cells and the ability of RK to bind various types of hormone receptors. While RK failed to stimulate fat breakdown in the absence of norepinephrine, it was successful in increasing hormone-induced fat breakdown. They discovered that RK has a fat burning activity that takes place via a mechanism unrelated to that of synephrine (from peppers). These results suggest that RK enhances hormone-induced fat breakdown via an increase in the translocation of enzymes from the cytosol to the lipid droplets in the fat cells.
Capsaicin (from peppers) was first reported to exert anti-obese activity by enhancing the energy metabolism. This effect might be due to an increase of thermogenesis in brown fat tissues through the stimulation of the sympathetic nervous system. If this is so, it follows that RK also stimulates the energy metabolism via a mechanism similar to that capsaicin. Capsaicin administration increases the oxygen consumption, while RK supplementation increases the oxygen consumption and reduces the respiratory quotient. In another study, the effect of RK on energy metabolism was examined by measuring oxidation levels in fat cells. Both the specific activity and total activity of oxidation activity were significantly increased by RK. These results indicate that RK activates thermogenesis and enhances energy metabolism from fat. In any case, more detailed studies in the future will help clarify the exact mechanisms by which RK enhances fat metabolism and breakdown.
In conclusion, the present study demonstrated that RK has an anti-obese function. RK stimulated the metabolism of white and brown fat tissues and inhibited small intestinal absorption of dietary fat by suppressing pancreatic enzyme activity. As an agent effective in preventing both fat- and sugar-induced obesity, RK might exert its anti-obesity effect via an increase of hormone-induced fat breakdown in white fat cells and an enhancement of thermogenesis in brown fat cells.
Garcinia Cambogia extract (hydroxycitric acid HCA)
Garcinia is a tree native to the evergreen forests of India, Nepal, and Sri Lanka and is historically used for both food and medicinal purposes. It produces small, green fruit about 2 inches in diameter that resemble pumpkins. Although numerous chemicals have been isolated from G. cambogia fruit, hydroxycitric acid (HCA) is considered the most prominent ingredient for weight loss. Several clinical studies on the efficacy for obesity have been conducted, including 8 publications revealing randomized, double-blind, placebo-controlled trials that evaluated the effects of G. cambogia on body weight in patients who were overweight.
Selected clinical findings
- Effects of a natural extract of hydroxycitric acid (HCA) and a combination of HCA plus niacin‐bound chromium and Gymnema sylvestre extract on weight loss 
The efficacy of optimal doses of highly bioavailable hydroxycitric acid (HCA) alone and in combination with niacin‐bound chromium (NBC) and a standardized Gymnema sylvestre extract (GSE) on weight loss in moderately obese subjects was evaluated by monitoring changes in body weight, body mass index (BMI), appetite, lipid profiles, serum leptin and excretion of urinary fat metabolites. HCA has been shown to reduce appetite, inhibit fat synthesis and decrease body weight without stimulating the central nervous system. NBC has demonstrated its ability to maintain healthy insulin levels, while GSE has been shown to regulate weight loss and blood sugar levels. A randomized, double‐blind, placebo‐controlled human study was conducted with 60 moderately obese subjects (ages 21–50). Subjects were randomly divided into three groups. Group A was administered HCA, group B was administered a combination of HCA, NBC and GSE, while group C was given placebo daily in three equally divided doses 30–60 min before meals. All subjects received a 2000 kcal diet per day and participated in supervised walking.
Fig. 3. Hydroxycitric acid (HCA) from Garcinia Cambogia causes study participants to leave food on their plates after eating, indicating fullness.
Fig 4. Hydroxycitric acid (HCA) from Garcinia Cambogia decreases bad cholesterol, increases good cholesterol and lowers total circulating fat in the blood.
I, week 0; M, week 4; F, week 8.
HDL=high density lipoprotein (good cholesterol)
LDL=low density lipoprotein (bad cholesterol)
Triglycerides (soluble fat in blood)
HCA, derived from the fruit rind of G. cambogia, has been used for culinary purposes in southern Asia for centuries to make meals more filling. HCA is known to reduce appetite, inhibit fat synthesis and decrease body weight without stimulating the central nervous system. Importantly HCA does not cause nervousness, rapid heart rate, high blood pressure or insomnia, symptoms that are often associated with dietary stimulants such as ephedra, caffeine or phenylpropanolamine .
HCA promotes weight reduction through suppressing new fat synthesis –. In the authors’ previous study and in this present study, they demonstrate other important mechanisms including appetite suppression by HCA and serotonin release by rat brain cortex, regulatory roles in the lowering of lipid profiles and serum leptin levels and increased fat oxidation as demonstrated by enhanced excretion of urinary fat metabolites , .
In examining some positive weight‐loss studies, a randomized, placebo‐controlled study on HCA was conducted involving 20 overweight adults, for a period of 2 months. It was demonstrated that 500 mg of HCA taken three times per day before meals resulted in 200% greater weight loss than those taking a placebo. This occurred without any side effects commonly associated with other dietary stimulants . Of added importance, a significant reduction was observed in cholesterol and triglyceride levels. Another study by demonstrated that a daily dose of 1.2 g of HCA along with a daily diet of 1200 kcal for 3 months resulted in a significant difference in weight loss to placebo . Furthermore, yet another randomized, placebo‐controlled, single‐blind, cross‐over study in 12 males and 12 females using a daily dose of 900 mg of HCA for 2 weeks demonstrated that HCA supplementation reduced 24‐hour energy intake while satiety was sustained and hunger was tempered .
It is important to note that this study was designed to utilize a highly bioavailable, water‐soluble form of HCA extracted from Garcinia, which leverages the same formulation methodology used by Umbrella Labs. Supplements were given on an empty stomach at least 30–60 min before meals to enhance bioavailability, which has been previously observed . Other formulations of Garcinia extract HCA on the market today use a calcium salt that is poorly soluble in water, resulting in compromised absorption by the body.
This study was designed to better determine the effects of HCA on satiety. Subjects were administered a 2000 kcal diet/day, and all remaining food was weighed after each meal to determine HCA effect on appetite reduction. Results demonstrated a significant reduction in appetite following supplementation of HCA alone or in combination with niacin (vitamin B3).
A statistically significant reduction in body weight was observed between start and middle of the experiment, but not between middle and end in the placebo, which signifies that a controlled diet and exercise initially result in weight reduction but eventually plateaus. This fact highlights the importance of a novel, efficacious safe supplement for weight management.
Perceived weight loss in both the HCA (group A) and HCA formula (group B) group is supported by the improvement in BMI, which implies a sparing of lean muscle and fat oxidation, as demonstrated by enhanced excretion of urinary fat metabolites. Muscle mass is denser and heavier, and thus, sparing lean muscle mass contributes to slow and steady fat loss that is preferable to most people.
Downregulation of obesity regulatory genes may also be an additional mechanism of HCA's ability to reduce body weight and appetite. Leptin, a hormone and a biomarker of the obesity regulation, is synthesized and secreted by fat cells and is present in the bloodstream and is directly related to body fat. Leptin binds to receptors in the brain and activates signals that inhibit food intake and increase energy expenditure]. Leptin resistance develops when receptor‐binding activity is diminished and, as a result, plasma leptin levels increase, which in turn lose their ability to inhibit food intake and increase energy expenditure. Generally, blood levels of leptin are higher in overweight individuals than in normal individuals and higher in women than in men. Leptin has been shown to be able to modulate insulin secretion and activity. In the present study, it was shown that supplementation with HCA alone significantly decreases serum leptin levels, which may play a significant role in downregulating obesity regulatory genes.
In summary these clinical findings demonstrate that Garcinia extract HCA alone or in combination with niacin, given 30–60 min before meals, is highly bioavailable, efficacious and safe as a weight‐management solution. Furthermore, this study also revealed that HCA alone or in combination with niacin effectively causes fat degradation and beneficially regulate lipid profiles and serum leptin levels. The reduced weight loss, BMI, serum leptin levels, appetite, food intake and increased fat oxidation indicate that supplementation with HCA represents a novel therapeutic tool for weight management.
Green tea extract (EGCG)
Green tea extract is rich in Epigallocatechin gallate (EGCG), its most abundant and potent antioxidant . During the past decade, the health-promoting effects of green tea and its constituent polyphenols has been intensively researched. Flavonoids such as EGCG are the most important polyphenols in tea leaves and they also make up the major components of green tea infusions. The antioxidant activity of EGCG is chiefly due to its ability to chelate metal ions. Deficiencies in metals homeostasis can lead to oxidative stress, which manifests in chronic diseases like diabetes, cardiovascular disease, atherosclerosis and cancer –. However the most exciting and well-studied aspect of EGCG is its ability to reduce body weight and fat mass. Excitingly, more recent research is focusing on the ability of EGCG to also prevent age-associated cognitive impairment and age-associated senescense (i.e. cellular exhaustion). In addition, EGCG consumption favorably affects oxidative stress markers specifically in weight-trained men .
Selected clinical findings
- Therapeutic effect of high-dose green tea extract on weight reduction: A randomized, double-blind, placebo-controlled clinical trial 
Background and aims: To examine the effect and safety of high-dose green tea extract (Epigallocatechin gallate, EGCG) weight reduction and changes of lipid profile and obesity-related hormone peptides in women with central obesity. Methods: We conducted a randomized, double-blind trial registered under ClinicalTrials.gov Identifier no. NCT02147041. A total of 115 overweight individuals were screened at our clinic. 102 of them with a body mass index (BMI) ≥ 27 kg/m2 and a waist circumference (WC) ≥ 80 cm were eligible for the study. These patients were randomly assigned to either a high-dose green tea group or placebo group. The total treatment time was 12 weeks. The main outcome measures were anthropometric measurements, lipid profiles, and obesity related hormone peptides including leptin, adiponectin, ghrelin, and insulin.
Fig. 5. EGCG supplementation reduces BMI, waist circumference
*p-value is statistically significant
Fig.6. Summary of main results from 4 clinical trials of EGCG –
The potential of green tea as a natural agent of weight loss has been investigated in numerous studies similar to the above , . Some authors suggest that the polyphenolic components of green tea have an anti-obese effect on fat homeostasis, by increasing thermogenesis, reducing fat absorption, and introducing modifications in appetite. The results obtained in this study (significant differences in BMI between the green tea extract group and the placebo group) further support role of green tea in weight loss.
A number of experimental studies have been conducted to examine the effects of green tea extract on carbohydrate metabolism and lipid profile , , . These studies have concluded that the most active component in green tea extract with respect to weight loss management are polyphenols, with EGCG being the most crucial. Abnormalities of lipid metabolism are one of the major risk factors for the development of cardiovascular disease, and very often associated with obesity. The outcomes of the above studies show that a 3 month supplementation has a positive effect on lipid profile in overweight patients. Decreases in total cholesterol were consistently observed, along with increases in “good cholesterol”. The positive effect of green tea extract in human studies has also been observed by others. The results could be partly caused by the decreased absorption of cholesterol and glucose from the diet in the presence of the polyphenols from green tea extract in the small intestine, especially if the supplement is taken by subjects during meals .
Overall, each of the above studies showed a beneficial influence of green tea extract on oxidative stress in the body, and weight management. Green tea extract and EGCG specifically eliminate reactive oxygen and nitric radicals, and also act as chelators of metal ions active in the system redox. Free radicals and active metal ions are highly toxic because of their destructive effect on lipids, proteins, and DNA. As a result, the profound ability of green tea extract and EGCG to mitigate these effects are considered to be the primary underlying biological effect of green tea extract in general.
- Consumption of green tea favorably affects oxidative stress markers in weight-trained men 
Objective: This study investigated the effects of the consumption of green tea (GT) for 7 days on biomarkers of oxidative stress in young men undergoing resistance exercise. Methods: Fourteen subjects performed a bench press exercise (four sets, 10 to 4 repetitions) after undergoing a period without (control group) or with the intake of GT (GT group; 2 g of leaves in 200 mL of water, three times per day). Blood samples were obtained before and after exercise and analyzed for total antioxidant capacity (ferric reducing ability of plasma [FRAP]), total polyphenols, reduced glutathione (GSH), lipid hydroperoxide (LH) and thiobarbituric acid–reactive substances, creatine kinase (CK), aspartate aminotransferase (AST), xanthine oxidase (XO), hypoxanthine, and uric acid (UA).
Fig. 7. Lipid peroxide levels after exercise in weight-trained men. Green tea consumption reduces the generation of harmful peroxides that result from load-bearing exercise.
Fig. 8. Blood concentration of glutathione (GSH), the body’s most important self-generated antioxidant, after exercise in weight-trained men. Green tea consumption increases the generation of beneficial glutathione that resists loss after load-bearing exercise.
In this study the authors investigated the effect of green tea intake on oxidative stress before and after resistance exercise, using blood biochemical markers in healthy male subjects. The protective effects of green tea were demonstrated through the significant reductions in plasma lipid hydroperoxide concentrations just before and at 15 min after exercise, even in the absence of evident exercise-induced oxidative damag. Lipid hydroperoxides are considered an important biomarker to indicate early stages of lipid peroxidation (ie. the biological process by which fat becomes toxic). Thus, these results appear to confirm the antioxidant potential of green tea extract in protecting lipid structures of the body , .
The intervention with green tea significantly enhanced the blood concentrations of protective glutathione (GSH) across the board. These findings support the existing evidence that supplementation with antioxidants may decrease the oxidation of blood GSH after exercise , . Furthermore, these findings demonstrate that dietary strategies, such as daily green tea intake, may also benefit the glutathione system of athletes by elevating blood GSH levels before and after effort. The green tea efficiency in preventing the blood GSH decrease at 15 min after exercise is in accordance with other studies, which did not include exercise, in which green tea administration prevented the decrease in blood and tissue concentrations of GSH induced by oxidative stress , . Taken together, these results suggest that intense resistance exercises can elicit an increase in the use of components of the blood antioxidant system, particularly those directed to neutralize and/or remove the lipid peroxidation metabolites, such as glutathione GSH.
Overall, this study suggests that green tea extract offers protection against oxidative damaged induced by resistance exercise. The adequate intake of dietary antioxidants among physically active populations must be considered.
Umbrella Supplements Green Coffee Bean extract with Raspberry Ketone extract, Garcinia Cambogia extract, Green tea extract and caffeine is specially formulated based on peer-reviewed clinical data, ensuring optimal efficacy for weight loss management while boosting fat-burning metabolism and promoting uniform energy levels throughout the day.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases.
 Y. Fukushima et al., “Coffee and green tea as a large source of antioxidant polyphenols in the Japanese population,” J. Agric. Food Chem., vol. 57, no. 4, pp. 1253–1259, Feb. 2009.
 Z. Gorji et al., “The effect of green-coffee extract supplementation on obesity: A systematic review and dose-response meta-analysis of randomized controlled trials,” Phytomedicine, vol. 63. Elsevier GmbH, 01-Oct-2019.
 T. Watanabe, S. Kobayashi, T. Yamaguchi, M. Hibi, I. Fukuhara, and N. Osaki, “Coffee Abundant in Chlorogenic Acids Reduces Abdominal Fat in Overweight Adults: A Randomized, Double-Blind, Controlled Trial,” Nutrients, vol. 11, no. 7, p. 1617, Jul. 2019.
 E. Thom, “The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people,” J. Int. Med. Res., vol. 35, no. 6, pp. 900–908, 2007.
 K. Kempf et al., “Cardiometabolic effects of two coffee blends differing in content for major constituents in overweight adults: a randomized controlled trial,” Eur. J. Nutr., vol. 54, no. 5, pp. 845–854, Aug. 2015.
 T. Nagao, R. Ochiai, T. Watanabe, … K. K.-J. P., and undefined 2009, “Visceral fat-reducing effect of continuous coffee beverage consumption in obese subjects.”
 H. Roshan, O. Nikpayam, M. Sedaghat, and G. Sohrab, “Effects of green coffee extract supplementation on anthropometric indices, glycaemic control, blood pressure, lipid profile, insulin resistance and appetite in patients with the metabolic syndrome: A randomised clinical trial,” Br. J. Nutr., vol. 119, no. 3, pp. 250–258, Feb. 2018.
 C. Bobillo et al., “Short-term effects of a green coffee extract-, Garcinia c ambogia- and l-carnitine-containing chewing gum on snack intake and appetite regulation,” Eur. J. Nutr., vol. 57, no. 2, pp. 607–615, Mar. 2018.
 O. Nikpayam, M. Najafi, S. Ghaffari, M. A. Jafarabadi, G. Sohrab, and N. Roshanravan, “Effects of green coffee extract on fasting blood glucose, insulin concentration and homeostatic model assessment of insulin resistance (HOMA-IR): A systematic review and meta-analysis of interventional studies,” Diabetology and Metabolic Syndrome, vol. 11, no. 1. BioMed Central Ltd., 05-Nov-2019.
 NAGAO and T, “Hydroxyhydroquinone-reduced milk coffee decreases blood pressure in individuals with mild hypertension and high-normal blood pressure,” Prog. Med., vol. 27, pp. 2649–2664, 2007.
 R. Ochiai, Y. Sugiura, Y. Shioya, K. Otsuka, Y. Katsuragi, and T. Hashiguchi, “Coffee polyphenols improve peripheral endothelial function after glucose loading in healthy male adults,” Nutr. Res., vol. 34, no. 2, pp. 155–159, Feb. 2014.
 I. Park et al., “Effects of subacute ingestion of chlorogenic acids on sleep architecture and energy metabolism through activity of the autonomic nervous system: A randomised, placebo-controlled, double-blinded cross-over trial,” Br. J. Nutr., vol. 117, no. 7, pp. 979–984, Apr. 2017.
 K. Saitou et al., “Effect of Chlorogenic Acids on Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Trial,” Nutrients, vol. 10, no. 10, p. 1337, Sep. 2018.
 J. A. Greenberg, C. N. Boozer, and A. Geliebter, “Coffee, diabetes, and weight control,” American Journal of Clinical Nutrition, vol. 84, no. 4. pp. 682–693, 01-Oct-2006.
 T. Bakuradze et al., “Antioxidant-rich coffee reduces DNA damage, elevates glutathione status and contributes to weight control: Results from an intervention study,” Mol. Nutr. Food Res., vol. 55, no. 5, pp. 793–797, May 2011.
 Y. Matsuzawa et al., “New criteria for ‘obesity disease’ in Japan,” Circ. J., vol. 66, no. 11, pp. 987–992, Nov. 2002.
 N. Ota, S. Soga, T. Murase, A. Shimotoyodome, and T. Hase, “Consumption of Coffee Polyphenols Increases Fat Utilization in Humans,” J. Heal. Sci., vol. 56, no. 6, pp. 745–751, 2010.
 T. Murase et al., “Coffee polyphenols suppress diet-induced body fat accumulation by downregulating SREBP-1c and related molecules in C57BL/6J mice,” Am. J. Physiol. - Endocrinol. Metab., vol. 300, no. 1, Jan. 2011.
 C. Morimoto, Y. Satoh, M. Hara, S. Inoue, T. Tsujita, and H. Okuda, “Anti-obese action of raspberry ketone,” Life Sci., vol. 77, no. 2, pp. 194–204, May 2005.
 P. Hartog, “CNN. com Health Report: Dietary supplement warning system lacking,” 2001.
 B. S. Jena, G. K. Jayaprakasha, R. P. Singh, and K. K. Sakariah, “Chemistry and Biochemistry of (−)-Hydroxycitric Acid from Garcinia,” J. Agric. Food Chem., vol. 50, no. 1, pp. 10–22, Jan. 2002.
 J. M. Lowenstein, “Effect of (-)-hydroxycitrate on fatty acid synthesis by rat liver in vivo.,” J. Biol. Chem., vol. 246, no. 3, pp. 629–632, Feb. 1971.
 B. S. Jena, G. K. Jayaprakasha, R. P. Singh, and K. K. Sakariah, “Chemistry and biochemistry of (-)-hydroxycitric acid from Garcinia,” Journal of Agricultural and Food Chemistry, vol. 50, no. 1. pp. 10–22, 2002.
 S. E. Ohia, C. A. Opere, A. M. LeDay, M. Bagchi, D. Bagchi, and S. J. Stohs, “Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX),” Mol. Cell. Biochem., vol. 238, no. 1/2, pp. 89–103, 2002.
 R. D. Mattes and L. Bormann, “Effects of (-)-hydroxycitric acid on appetitive variables.,” Physiol. Behav., vol. 71, no. 1–2, pp. 87–94.
 Y. C. Loe, N. Bergeron, N. Rodriguez, and J.-M. Schwarz, “Gas Chromatography/Mass Spectrometry Method to Quantify Blood Hydroxycitrate Concentration,” Anal. Biochem., vol. 292, no. 1, pp. 148–154, May 2001.
 J. D. Lambert and R. J. Elias, “The antioxidant and pro-oxidant activities of green tea polyphenols: A role in cancer prevention,” Arch. Biochem. Biophys., vol. 501, no. 1, pp. 65–72, Sep. 2010.
 I. Rady, H. Mohamed, M. Rady, I. A. Siddiqui, and H. Mukhtar, “Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea,” Egypt. J. Basic Appl. Sci., vol. 5, no. 1, pp. 1–23, Mar. 2018.
 H.-S. Kim, M. J. Quon, and J. Kim, “New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate,” Redox Biol., vol. 2, pp. 187–195, Jan. 2014.
 K. Jomova and M. Valko, “Advances in metal-induced oxidative stress and human disease,” Toxicology, vol. 283, no. 2–3, pp. 65–87, May 2011.
 V. S. P. Panza, E. Wazlawik, G. Ricardo Schütz, L. Comin, K. C. Hecht, and E. L. da Silva, “Consumption of green tea favorably affects oxidative stress markers in weight-trained men,” Nutrition, vol. 24, no. 5, pp. 433–442, May 2008.
 S. Legeay, M. Rodier, L. Fillon, S. Faure, and N. Clere, “Epigallocatechin Gallate: A Review of Its Beneficial Properties to Prevent Metabolic Syndrome.,” Nutrients, vol. 7, no. 7, pp. 5443–68, Jul. 2015.
 P. Bogdanski, J. Suliburska, M. Szulinska, M. Stepien, D. Pupek-Musialik, and A. Jablecka, “Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients,” Nutr. Res., vol. 32, no. 6, pp. 421–427, Jun. 2012.
 I.-J. Chen, C.-Y. Liu, J.-P. Chiu, and C.-H. Hsu, “Therapeutic effect of high-dose green tea extract on weight reduction: A randomized, double-blind, placebo-controlled clinical trial,” Clin. Nutr., vol. 35, no. 3, pp. 592–599, Jun. 2016.
 A. Basu et al., “Green Tea Supplementation Affects Body Weight, Lipids, and Lipid Peroxidation in Obese Subjects with Metabolic Syndrome,” J. Am. Coll. Nutr., vol. 29, no. 1, pp. 31–40, Feb. 2010.
 J. Suliburska, P. Bogdanski, M. Szulinska, M. Stepien, D. Pupek-Musialik, and A. Jablecka, “Effects of green tea supplementation on elements, total antioxidants, lipids, and glucose values in the serum of obese patients.,” Biol. Trace Elem. Res., vol. 149, no. 3, pp. 315–22, Dec. 2012.
 T. M. Rains, S. Agarwal, and K. C. Maki, “Antiobesity effects of green tea catechins: a mechanistic review,” J. Nutr. Biochem., vol. 22, no. 1, pp. 1–7, Jan. 2011.
 N. Thavanesan, “The putative effects of green tea on body fat: an evaluation of the evidence and a review of the potential mechanisms,” Br. J. Nutr., vol. 106, no. 9, pp. 1297–1309, Nov. 2011.
 A. L. Brown et al., “Effects of dietary supplementation with the green tea polyphenol epigallocatechin-3-gallate on insulin resistance and associated metabolic risk factors: randomized controlled trial,” Br. J. Nutr., vol. 101, no. 6, pp. 886–894, Aug. 2008.
 L.-Y. Wu, C.-C. Juan, L.-T. Ho, Y.-P. Hsu, and L. S. Hwang, “Effect of Green Tea Supplementation on Insulin Sensitivity in Sprague−Dawley Rats,” J. Agric. Food Chem., vol. 52, no. 3, pp. 643–648, Feb. 2004.
 S. Frejnagel and M. Wroblewska, “Comparative Effect of Green Tea, Chokeberry and Honeysuckle Polyphenols on Nutrients and Mineral Absorption and Digestibility in Rats,” Ann. Nutr. Metab., vol. 56, no. 3, pp. 163–169, 2010.
 Q. Y. Zhu, Y. Huang, D. Tsang, and Z.-Y. Chen, “Regeneration of α-Tocopherol in Human Low-Density Lipoprotein by Green Tea Catechin,” J. Agric. Food Chem., vol. 47, no. 5, pp. 2020–2025, May 1999.
 N. Salah, N. J. Miller, G. Paganga, L. Tijburg, G. P. Bolwell, and C. Riceevans, “Polyphenolic Flavanols as Scavengers of Aqueous Phase Radicals and as Chain-Breaking Antioxidants,” Arch. Biochem. Biophys., vol. 322, no. 2, pp. 339–346, Oct. 1995.
 P. V. A. Babu, K. E. Sabitha, and C. S. Shyamaladevi, “Therapeutic effect of green tea extract on oxidative stress in aorta and heart of streptozotocin diabetic rats,” Chem. Biol. Interact., vol. 162, no. 2, pp. 114–120, Aug. 2006.
 E. Skrzydlewska, J. Ostrowska, R. Farbiszewski, and K. Michalak, “Protective effect of green tea against lipid peroxidation in the rat liver, blood serum and the brain,” Phytomedicine, vol. 9, no. 3, pp. 232–238, Jan. 2002.